In:
The Journal of Experimental Medicine, Rockefeller University Press, Vol. 124, No. 4 ( 1966-10-01), p. 773-785
Abstract:
A strain of rabbits with an inherited complement deficiency was shown to lack the sixth component of the hemolytic complement system. A method was elaborated for the partial purification of this component from normal rabbit serum. Upon injection of partially purified rabbit C'6 into C'6-deficient animals, an antibody was obtained which specifically inhibited the hemolytic activity of C'6. The data suggest that C'6-deficient serum either lacks the C'6 molecule or contains it in a chemically modified and inactive form.
Type of Medium:
Online Resource
ISSN:
1540-9538
,
0022-1007
DOI:
10.1084/jem.124.4.773
Language:
English
Publisher:
Rockefeller University Press
Publication Date:
1966
detail.hit.zdb_id:
1477240-1