In:
The Journal of experimental medicine, Rockefeller University Press, Vol. 177, No. 1 ( 1993-01-01), p. 185-190
Kurzfassung:
Lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 (LFA-1/ICAM-1)-and very late antigen 4/vascular cell adhesion molecule 1 (VLA-4/VCAM-1)-mediated adhesion of T lymphocytes to endothelial cells (EC) can be regulated by increased expression of ICAM-1 and VCAM-1 upon cytokine treatment of EC, or by activation of the integrin molecules LFA-1 and VLA-4 on T cells. Here, we provide evidence that preferential usage of LFA-1 over VLA-4 is yet another mechanism to control T cell adhesion. We observed that binding of activated T lymphocytes, as opposed to resting T cells, to EC is essentially mediated through LFA-1 and not through VLA-4. VLA-4-mediated adhesion of T cells to EC is only found when LFA-1 is not expressed or not functional, as observed for several T cell leukemia cell lines. These results suggest that LFA-1-mediated adhesion dominates and may downregulate VLA-4-mediated adhesion through an unidentified mechanism.
Materialart:
Online-Ressource
ISSN:
0022-1007
,
1540-9538
DOI:
10.1084/jem.177.1.185
Sprache:
Englisch
Verlag:
Rockefeller University Press
Publikationsdatum:
1993
ZDB Id:
1477240-1