In:
Molecular Biology of the Cell, American Society for Cell Biology (ASCB), Vol. 13, No. 5 ( 2002-05), p. 1778-1791
Abstract:
The endoplasmic reticulum (ER) is divided into rough and smooth domains (RER and SER). The two domains share most proteins, but RER is enriched in some membrane proteins by an unknown mechanism. We studied RER protein targeting by expressing fluorescent protein fusions to ER membrane proteins in Caenorhabditis elegans. In several cell types RER and general ER proteins colocalized, but in neurons RER proteins were concentrated in the cell body, whereas general ER proteins were also found in neurites. Surprisingly RER membrane proteins diffused rapidly within the cell body, indicating they are not localized by immobilization. Ribosomes were also concentrated in the cell body, suggesting they may be in part responsible for targeting RER membrane proteins.
Type of Medium:
Online Resource
ISSN:
1059-1524
,
1939-4586
DOI:
10.1091/mbc.01-10-0514
Language:
English
Publisher:
American Society for Cell Biology (ASCB)
Publication Date:
2002
detail.hit.zdb_id:
1474922-1
SSG:
12