In:
Crohn's & Colitis 360, Oxford University Press (OUP)
Abstract:
Successful Crohn's disease (CD) therapy relies on timely and precise management strategies. Endoscopic balloon dilation (EBD) has been applied as a first-line treatment for symptomatic CD-associated strictures due to its minimally invasive nature and possibility of preserving intestinal length. Objective The aim of the present study was to determine patient-related predictive factors associated with the need for surgery for CD-associated ileocolic strictures after technically successful EBD. Methods All original studies published before December 2023 that reported the outcomes of patients treated with EBD for ileocolic strictures secondary to CD and described follow-up for at least 1 year were included. The difference in risk of needing surgery was calculated for eight different patient characteristics (Sex, smoking habit, previous surgery, biologic therapy, steroids, immunosuppressors, nature of the stricture, endoscopic disease activity). Results There were significant differences in the risk of needing surgery after EBD among patients who underwent surgery and patients without a history of surgery [RD: -0.20 (-0.31, -0.08)], patients with endoscopic mucosal activity and patients in remission at the time of EBD [RD: 0.19 (0.04, 0.34)] , patients using biologics at the time of EBD and patients not using biologics [RD: -0.09 (-0.16, -0.03)], and patients using steroids and those not using steroids at the time of EBD [RD: 0.16 (0.07, 0.26)] . Conclusion The use of biologics and endoscopic disease remission at the time of EBD were protective factors against the need for surgery. No previous surgery or use of steroids at the time of EBD was associated with the need for surgery during follow-up.
Type of Medium:
Online Resource
ISSN:
2631-827X
DOI:
10.1093/crocol/otae041
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2024
detail.hit.zdb_id:
3040498-8