In:
European Heart Journal. Acute Cardiovascular Care, Oxford University Press (OUP), Vol. 11, No. 11 ( 2022-11-30), p. 797-805
Abstract:
Using the principles of clinical governance, a patient-centred approach intended to promote holistic quality improvement, we designed a prospective, multicentre study in patients with acute coronary syndrome (ACS). We aimed to verify and quantify consecutive inclusion and describe relative and absolute effects of indicators of quality for diagnosis and therapy. Methods and results Administrative codes for invasive coronary angiography and acute myocardial infarction were used to estimate the ACS universe. The ratio between the number of patients included and the estimated ACS universe was the consecutive index. Co-primary quality indicators were timely reperfusion in patients admitted with ST-elevation ACS and optimal medical therapy at discharge. Cox-proportional hazard models for 1-year death with admission and discharge-specific covariates quantified relative risk reductions and adjusted number needed to treat (NNT) absolute risk reductions. Hospital codes tested had a 99.5% sensitivity to identify ACS universe. We estimated that 7344 (95% CI: 6852–7867) ACS patients were admitted and 5107 were enrolled—i.e. a consecutive index of 69.6% (95% CI 64.9–74.5%), which varied from 30.7 to 79.2% across sites. Timely reperfusion was achieved in 22.4% (95% CI: 20.7–24.1%) of patients, was associated with an adjusted hazard ratio (HR) for 1-year death of 0.60 (95% CI: 0.40–0.89) and an adjusted NNT of 65 (95% CI: 44–250). Corresponding values for optimal medical therapy were 70.1% (95% CI: 68.7–71.4%), HR of 0.50 (95% CI: 0.38–0.66), and NNT of 98 (95% CI: 79–145). Conclusion A comprehensive approach to quality for patients with ACS may promote equitable access of care and inform implementation of health care delivery. Registration ClinicalTrials.Gov ID NCT04255537
Type of Medium:
Online Resource
ISSN:
2048-8726
,
2048-8734
DOI:
10.1093/ehjacc/zuac106
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2022
detail.hit.zdb_id:
2663340-1
