In:
The Journal of Infectious Diseases, Oxford University Press (OUP), Vol. 227, No. 3 ( 2023-02-01), p. 364-370
Abstract:
Trends in estimates of US pediatric SARS-CoV-2 infection-induced seroprevalence from commercial laboratory specimens may overrepresent children with frequent health care needs. We examined seroprevalence trends and compared seroprevalence estimates by testing type and diagnostic coding. Methods Cross-sectional convenience samples of residual sera September 2021-February 2022 from 52 US jurisdictions were assayed for infection-induced SARS-CoV-2 antibodies; monthly seroprevalence estimates were calculated by age group. Multivariate logistic analyses compared seroprevalence estimates for specimens associated with International Classification of Diseases-Tenth Revision (ICD-10) codes and laboratory orders indicating well-child care with estimates for other pediatric specimens. Results Infection-induced SARS-CoV-2 seroprevalence increased in each age group, from 30% to 68% (1–4 years), 38% to 77% (5–11 years), and 40% to 74% (12–17 years). On multivariate analysis, patients with well-child ICD-10 codes were seropositive more often than other patients aged 1–17 years (adjusted prevalence ratio [aPR] 1.04; 95% confidence interval [CI] , 1.02–1.07); children aged 9–11 years receiving standard lipid screening were seropositive more often than those receiving other laboratory tests (aPR, 1.05; 95% CI, 1.02–1.08). Conclusions Infection-induced seroprevalence more than doubled among children younger than 12 years between September 2021 and February 2022, and increased 85% in adolescents. Differences in seroprevalence by care type did not substantially impact US pediatric seroprevalence estimates.
Type of Medium:
Online Resource
ISSN:
0022-1899
,
1537-6613
DOI:
10.1093/infdis/jiac423
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2023
detail.hit.zdb_id:
1473843-0
