In:
Journal of the Pediatric Infectious Diseases Society, Oxford University Press (OUP), Vol. 11, No. 6 ( 2022-06-22), p. 267-273
Abstract:
The immunologic features of children with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not clearly delineated. This study was conducted to evaluate SARS-CoV-2-specific antibody responses in children with COVID-19. Methods The levels of anti-spike (S) IgG, anti-SARS-CoV-2 IgG, and neutralizing antibody (NAb) were measured during various time points in children & lt;19 years of age with COVID-19 in South Korea from February 2020 to September 2020. Results One hundred sixty-five blood samples from 114 children with COVID-19 (43.9% asymptomatic and 56.1% mildly symptomatic) were analyzed. In both asymptomatic and mildly symptomatic children, the positive rates of anti-S IgG, anti-SARS-CoV-2 IgG, and NAb were low within 7 days after onset, but they soon reached 100% 14 to & lt;28 days after onset. In symptomatic children, the geometric mean titers (GMTs) of antibodies were all below the positive cutoff during the first 2 weeks from onset and peaked at 28 to & lt;56 days (5.6 for anti-S IgG, 383.6 for anti-SARS-CoV-2 IgG, and 55.0 for NAb, P & lt; .001, respectively). Antibody levels remained detectable up to 3 months after infection. The antibody GMTs during the period 14 to & lt;56 days after symptom onset were highest in children aged 0-4 years. Conclusions These results collectively present the humoral immune responses during SARS-CoV-2 infection in children. A further longitudinal study is needed to thoroughly understand the immune system and for effective vaccine development in children during the COVID-19 pandemic.
Type of Medium:
Online Resource
ISSN:
2048-7207
DOI:
10.1093/jpids/piac012
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2022
detail.hit.zdb_id:
2668791-4
