In:
Nucleic Acids Research, Oxford University Press (OUP), Vol. 36, No. 16 ( 2008-09-01), p. 5335-5349
Kurzfassung:
The tumor suppressor, p53, is a transcription factor which can modulate the transcription of a number of target genes that are involved in cell-cycle arrest and apoptosis. However, the apoptotic pathway mediated by p53 is not fully understood. Here, we showed that N-Myc downstream-regulated gene 2 (NDRG2) is a new target gene that is regulated by p53. NDRG2 mRNA and protein levels can be upregulated in a p53-dependent manner. The first intron of the NDRG2 gene contains a site that binds p53 directly and mediates wild-type p53-dependent transactivation. In addition, silencing of NDRG2 attenuates p53-mediated apoptosis, whereas over-expression of NDRG2 suppresses tumor cell growth, regardless of the presence or absence of p53. Our results indicate that NDRG2 is a novel p53-inducible target that is involved in the p53-mediated apoptosis pathway.
Materialart:
Online-Ressource
ISSN:
1362-4962
,
0305-1048
Sprache:
Englisch
Verlag:
Oxford University Press (OUP)
Publikationsdatum:
2008
ZDB Id:
1472175-2
SSG:
12