In:
Open Forum Infectious Diseases, Oxford University Press (OUP)
Kurzfassung:
The incidence of type 2 diabetes mellitus (T2DM) has risen dramatically. In PLHIV, chronic disease (now & gt;15 cases/1000 in the general population worldwide) and long-term exposure to ART can alter metabolic processes early, favoring insulin resistance and T2DM. We retrospectively studied the incidence of T2DM and associated factors in the Cohort of the Spanish AIDS Research Network (CoRIS), a prospective cohort of PLHIV enrolled at diagnosis and before initiation of ART. Methods PLHIV were aged & gt;18 years and ART-naïve at inclusion. The incidence of new diagnoses of T2DM after initiation of ART (per 1000 person-years) was calculated. Predictors of a diagnosis of T2DM were identified using the Cox proportional hazards model adjusted for statistically significant and clinically relevant variables. Results Cumulative incidence was 5.9 (95%CI 5.1-6.7) per 1000 person-years, increasing significantly in persons & gt;50 years to 14.4 (95%CI 10.4-19.3) per 1000 person-years. Median time to diagnosis of T2DM was 27 months. Only age and higher education were significant. Interestingly, higher education was associated with a 33% reduction in the incidence of T2DM. Having received TDF+(3TC or FTC)+RPV was almost significant as a protective factor (HR 0.49 [95%CI 0.24-1.01] p=0.05). Conclusions The incidence of T2DM in PLHIV in Spain was high, especially in persons & gt;50 years. Age was the factor most closely associated with onset and educational level the factor most associated with reduced risk. We highlight the lack of association between HIV-related factors and T2DM and show that, within NNRTI, rilpivirine could prove more benign for metabolic comorbidities.
Materialart:
Online-Ressource
ISSN:
2328-8957
DOI:
10.1093/ofid/ofae112
Sprache:
Englisch
Verlag:
Oxford University Press (OUP)
Publikationsdatum:
2024
ZDB Id:
2757767-3
