In:
Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 16, No. 6 ( 1996-11), p. 1373-1378
Abstract:
Hemorrhagic transformation after cerebral ischemia is a well known clinical concern. The frequency of intact basal lamina (BL), identified by laminin antigen, in hemorrhagic and nonhemorrhagic zones after middle cerebral artery occlusion (MCA:O) and 3-h MCA:O with reperfusion in adolescent male baboons was assessed. Parenchymal hemoglobin was not detected prior to 24-h reperfusion. A significant decrease in the density of laminin (BL) in hemorrhagic zones (6.2 ± 2.4) compared with nonhemorrhagic ischemic zones (10.5 ± 2.4) (p 〈 0.05) and nonischemic basal ganglia (17.0 ± 2.7) (p 〈 0.01) was observed. Time-dependent changes in BL integrity appear linked to the extravasation of blood components.
Type of Medium:
Online Resource
ISSN:
0271-678X
,
1559-7016
DOI:
10.1097/00004647-199611000-00036
Language:
English
Publisher:
SAGE Publications
Publication Date:
1996
detail.hit.zdb_id:
2039456-1