In:
Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 20, No. 10 ( 2000-10), p. 1446-1456
Kurzfassung:
The biochemical characteristics of white matter damage (WMD) in preterm infants were assessed using magnetic resonance spectroscopy (MRS). The authors hypothesized that preterm infants with WMD at term had a persisting cerebral lactic alkalosis and reduced N-acetyl aspartate (NAA)/creatine plus phosphocreatine (Cr), similar to that previously documented in term infants weeks after perinatal hypoxia–ischemia (HI). Thirty infants (gestational age 27.9 ± 3.1 weeks, birth weight 1122 ± 445 g) were studied at postnatal age of 9.8 ± 4.1 weeks (corrected age 40.3 ± 3.9 weeks). Infants were grouped according to the presence or absence of WMD on magnetic resonance (MR) images. The peak area ratios of lactate/Cr, NAA/Cr, myo-inositol/Cr, and choline (Cho)/Cr were measured from an 8-cm 3 voxel in the posterior periventricular white matter (WM) using proton MRS. Intracellular pH (pH i ) was calculated using phosphorus MRS. Eighteen infants had normal WM on MR imaging; 12 had WMD. For infants with WMD, lactate/Cr and myo-inositol/Cr were related ( P 〈 0.01); lactate/Cr and pH i were not ( P = 0.8). In the WMD group, mean lactate/Cr and myo-inositol/Cr were higher ( P 〈 0.001, P 〈 0.05, respectively) than the normal WM group. There was no difference in the NAA/Cr, Cho/Cr, or pH i between the two groups, although pH i was not measured in all infants. These findings suggest that WMD in the preterm infant at term has a different biochemical profile compared with the term infant after perinatal HI.
Materialart:
Online-Ressource
ISSN:
0271-678X
,
1559-7016
DOI:
10.1097/00004647-200010000-00006
Sprache:
Englisch
Verlag:
SAGE Publications
Publikationsdatum:
2000
ZDB Id:
2039456-1
