In:
The Laryngoscope, Wiley, Vol. 114, No. 5 ( 2004-05), p. 906-910
Abstract:
Purpose: To determine the natural history and treatment outcomes for patients with Merkel cell carcinoma. Methods: Review of the literature. Results: The probability of regional node involvement at presentation exceeds 50%; few patients present with distant metastases. Comprehensive treatment of the primary site and regional lymphatics with surgery or radiotherapy results in the highest likelihood of cure. The role of adjuvant chemotherapy remains investigational. Conclusion: The probability of regional dissemination at diagnosis is high. The optimal treatment is resection of the primary tumor and treatment of the regional lymphatics. Resection of all gross tumor should be accomplished followed by local–regional radiotherapy in most patients.
Type of Medium:
Online Resource
ISSN:
0023-852X
,
1531-4995
DOI:
10.1097/00005537-200405000-00023
Language:
English
Publisher:
Wiley
Publication Date:
2004
detail.hit.zdb_id:
2026089-1
