In:
Journal of Head Trauma Rehabilitation, Ovid Technologies (Wolters Kluwer Health), Vol. 33, No. 4 ( 2018-07), p. 266-274
Abstract:
To investigate whether functional magnetic resonance imaging (fMRI) can be used to detect fatigue after traumatic brain injury (TBI). Setting: Neurorehabilitation clinic. Participants: Patients with TBI ( n = 57) and self-experienced fatigue more than 1 year postinjury, and age- and gender-matched healthy controls ( n = 27). Main Measures: Self-assessment scales of fatigue, a neuropsychological test battery, and fMRI scanning during performance of a fatiguing 27-minute attention task. Results: During testing within the fMRI scanner, patients showed a higher increase in self-reported fatigue than controls from before to after completing the task ( P 〈 .001). The patients also showed lower activity in several regions, including bilateral caudate, thalamus, and anterior insula (all P 〈 .05). Furthermore, the patients failed to display decreased activation over time in regions of interest: the bilateral caudate and anterior thalamus (all P 〈 .01). Left caudate activity correctly identified 91% of patients and 81% of controls, resulting in a positive predictive value of 91%. Conclusion: The results suggest that chronic fatigue after TBI is associated with altered striato-thalamic-cortical functioning. It would be of interest to study whether fMRI can be used to support the diagnosis of chronic fatigue in future studies.
Type of Medium:
Online Resource
ISSN:
0885-9701
DOI:
10.1097/HTR.0000000000000340
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2018
detail.hit.zdb_id:
2053481-4
