In:
Eye & Contact Lens: Science & Clinical Practice, Ovid Technologies (Wolters Kluwer Health), Vol. 49, No. 3 ( 2023-03), p. 127-134
Abstract:
Herpes simplex keratitis resistance to antiviral treatment presents a growing concern. The herpes simplex virus has many different mechanisms of resistance to antiviral treatment, which have been well described. Resistance to acyclovir occurs because of mutations in the viral thymidylate kinase and DNA polymerase that decrease this enzyme's affinity for its substrate. This article discusses factors that explain the prevalence of this resistance, the ability for recurrences in immunocompromised populations, current treatments for acyclovir-resistant herpes simplex keratitis, and novel therapies for this growing concern.
Type of Medium:
Online Resource
ISSN:
1542-2321
DOI:
10.1097/ICL.0000000000000952
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2023
detail.hit.zdb_id:
2084291-0