In:
Infectious Microbes and Diseases, Ovid Technologies (Wolters Kluwer Health), Vol. 2, No. 4 ( 2020-10-21), p. 160-166
Abstract:
Invasive infection caused by Streptococcus pyogenes emm 89 strains has been increasing in several countries linked to a recently emergent clade of emm 89 strains, designated clade 3. In Japan, the features of emm 89 S. pyogenes strains, such as clade classification, remains unknown. In this study, we collected emm 89 strains isolated from both streptococcal toxic shock syndrome (STSS) (89 STSS isolates) and noninvasive infections (72 non-STSS isolates) in Japan from 2011 to 2019, and conducted whole-genome sequencing and comparative analysis, which resulted in classification of a large majority into clade 3 regardless of disease severity. In addition, invasive disease-associated factors were found among emm 89 strains, including mutations of control of virulence sensor, and absence of the hylP1 gene encoding hyaluronidase. These findings provide new insights into genetic features of emm 89 strains.
Type of Medium:
Online Resource
ISSN:
2641-5917
DOI:
10.1097/IM9.0000000000000038
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2020
detail.hit.zdb_id:
3099364-7
