In:
Pancreas, Ovid Technologies (Wolters Kluwer Health), Vol. 50, No. 2 ( 2021-2), p. 167-175
Abstract:
The relationship between eosinophils and cancer prognosis is unknown. Therefore, we analyzed the relationship between circulating eosinophils and the survival of stage IIA and IIB pancreatic cancer patients who underwent surgical resection. Methods This study included a retrospective cohort of 67 consecutive patients. Patients were categorized into two different groups based on the optimal cutoff for pretreatment levels of each biomarker, according to the receiver operating characteristic curves. Results The Kaplan-Meier method showed that low eosinophil ( P = 0.0403), high neutrophil ( P = 0.0066), and high monocyte ( P = 0.0003) counts were associated with short overall survival (OS). Low lymphocyte-to-monocyte ratio ( P = 0.0194) and eosinophil-to-lymphocyte ratio (ELR) ( P = 0.0413) were associated with reduced OS. In multivariate analysis, histological differentiation ( P = 0.0014), high neutrophils ( P = 0.047), high monocytes ( P = 0.029), and low eosinophils ( P 〈 0.0001) were correlated with poorer OS. Histological differentiation ( P = 0.033), low lymphocyte-to-monocyte ratio ( P = 0.029), and low ELR ( P = 0.005) were correlated with poor OS and were significant independent prognostic factors of poor outcomes. Conclusions Low eosinophils and low ELR were significant independent prognostic factors of poor outcomes.
Type of Medium:
Online Resource
ISSN:
1536-4828
,
0885-3177
DOI:
10.1097/MPA.0000000000001731
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021
detail.hit.zdb_id:
2053902-2