In:
Journal of Thoracic Imaging, Ovid Technologies (Wolters Kluwer Health), Vol. 36, No. 3 ( 2021-05), p. 181-188
Abstract:
Left ventricular mass (LVM) is a predictor for adverse cardiovascular outcomes. Coronary atherosclerosis (coronary artery disease [CAD]) and concentric left ventricular (LV) remodeling are linked pathophysiologically by endothelial dysfunction. Aim: This study sought to determine the potential association between coronary atherosclerosis and LVM. Methods: A total of 2384 consecutive patients, without structural heart disease or a medical history of CAD, undergoing prospective mid-diastolic electrocardiogram-gated computed tomography coronary angiography were enrolled in the study. LVM and LV mid-diastolic volume were measured using semiautomated software and indexed to body surface area. The average LV mid-diastolic wall thickness and concentricity index (LVM/LV mid-diastolic volume) were calculated. According to the Agatston Score, the patients were divided into 3 groups (Agatston=0, 0.1 to 399.9, ≥400). Similarly, patients were also divided into 4 groups on the basis of the Total Plaque Score (TPS) (0, 1 to 4, 5 to 8, and ≥9). In addition, patients were categorized according to CAD (normal coronaries, nonobstructive CAD, and obstructive stenosis [obstruction 〉 50%]). The association between the different categories of CAD and LV measures was assessed. Results: Both left ventricular mass index (LVMi) and the LV concentricity index increased with TPS categories from 55.3±12.1, 57.4±11.7, 60.9±13.6, and 63.7±15.3 g/m 2 ( P 〈 0.05), and 0.935±0.424, 0.975±0.3273, 1.046±0.431, and 1.138±0.443 mL/g ( P 〈 0.01), respectively. A similar trend of increasing LVMi was observed with increasing Agatston Score ( P 〈 0.001) and CAD category ( P 〈 0.05). Conclusion: In patients without known structural heart disease, LVMi is independently associated with measures of CAD.
Type of Medium:
Online Resource
ISSN:
0883-5993
DOI:
10.1097/RTI.0000000000000511
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021
detail.hit.zdb_id:
2048799-X
