In:
Transplantation, Ovid Technologies (Wolters Kluwer Health), Vol. 103, No. 7 ( 2019-07), p. 1392-1404
Kurzfassung:
Understanding factors that contribute to liver discards and nonusage is urgently needed to improve organ utilization. Methods. Using Scientific Registry of Transplant Recipient data, we studied a national cohort of all US adult, deceased brain dead donor, isolated livers available for transplantation from 2003 to 2016, including organ-specific and system-wide factors that may affect organ procurement and discard rates. Results. Of 73 686 available livers, 65 316 (88.64%) were recovered for transplant, of which 6454 (9.88%) were ultimately discarded. Livers that were not procured or, on recovery, discarded were more frequently from older, heavier, hepatitis B virus (HCV)+, and more comorbid donors ( P 〈 0.001). However, even after adjustment for organ quality, the odds of liver nonusage were 11% higher on the weekend (defined as donor procurements with cross-clamping occurring from 5:00 pm Friday until 11:59 am Sunday) compared with weekdays ( P 〈 0.001). Nonuse rates were also higher at night ( P 〈 0.001), defined as donor procurements with cross-clamping occurring from 5:00 pm to 5:00 am ; however, weekend nights had significantly higher nonuse rates compared with weekday nights ( P = 0.005). After Share 35, weekend nonusage rates decreased from 21.77% to 19.51% but were still higher than weekday nonusage rates ( P = 0.065). Weekend liver nonusage was higher in all 11 United Network of Organ Sharing regions, with an absolute average of 2.00% fewer available livers being used on the weekend compared with weekdays. Conclusions. Although unused livers frequently have unfavorable donor characteristics, there are also systemic and operational factors, including time of day and day of the week a liver becomes available, that impact the chance of liver nonprocurement and discard.
Materialart:
Online-Ressource
ISSN:
0041-1337
DOI:
10.1097/TP.0000000000002533
Sprache:
Englisch
Verlag:
Ovid Technologies (Wolters Kluwer Health)
Publikationsdatum:
2019
ZDB Id:
2035395-9
