In:
Transplantation Direct, Ovid Technologies (Wolters Kluwer Health), Vol. 10, No. 4 ( 2024-04), p. e1601-
Kurzfassung:
Hypothermic machine perfusion (HMP) reduces renal injury in donation after circulatory death donors with a high Kidney Donor Profile Index (KDPI). This study aims to characterize the correlation between KDPI, HMP parameters, and donor vitals during the withdrawal period in predicting short- and long-term graft outcomes. Methods. ANOVA with Tukey’s honestly significant difference tests compared the relationship between average flow, average resistance, peak resistance, flow slope, and resistance slope on day 30, 1-y, and 3-y eGFR, and days of delayed graft function. Graft and recipient survival rates were assessed using Kaplan-Meier analysis. Results. The data for 72 grafts were suitable for analysis. Kidneys with KDPI 〉 50% had a significantly higher day 30, and 1-y posttransplant eGFR, if HMP average flow was 〉 150 mL/min, or the average resistance was 〈 0.15 mm Hg/mL/min, compared with kidneys with also KDPI 〉 50% but had not achieved the same pump parameters. There were no significant differences in the Kaplan-Meier analysis, considering recipient or graft survival, regardless of the KPDI score with 3- or 5-y outcomes. Conclusions. Use of average resistance and average flow from a HMP, in conjunction with KDPI, may be predictive of the short- and long-term function of donation after circulatory death kidney transplants.
Materialart:
Online-Ressource
ISSN:
2373-8731
DOI:
10.1097/TXD.0000000000001601
Sprache:
Englisch
Verlag:
Ovid Technologies (Wolters Kluwer Health)
Publikationsdatum:
2024
ZDB Id:
2890276-2
