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    Online Resource
    Online Resource
    The Royal Society ; 2011
    In:  Interface Focus Vol. 1, No. 1 ( 2011-02-06), p. 75-85
    In: Interface Focus, The Royal Society, Vol. 1, No. 1 ( 2011-02-06), p. 75-85
    Abstract: We computationally study whether it is possible to stimulate a neuronal population in such a way that its mean firing rate increases without an increase of the population's net synchronization. For this, we use coordinated reset (CR) stimulation, which has previously been developed to desynchronize populations of oscillatory neurons. Intriguingly, delivered to a population of predominantly silent FitzHugh–Nagumo or Hindmarsh–Rose neurons at sufficient stimulation amplitudes, CR robustly causes a multi-frequency activation: different Arnold tongues such as 1 : 1 or n  :  m entrained neuronal clusters emerge, which consist of phase-shifted sub clusters. Owing to the clustering pattern the neurons' timing is well balanced, so that in total there is no synchronization. Our findings may contribute to the development of novel and safe stimulation treatments that specifically counteract cerebral hypo-activity without promoting pathological synchronization or inducing epileptic seizures.
    Type of Medium: Online Resource
    ISSN: 2042-8898 , 2042-8901
    Language: English
    Publisher: The Royal Society
    Publication Date: 2011
    detail.hit.zdb_id: 2585655-8
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