In:
Philosophical Transactions of the Royal Society B: Biological Sciences, The Royal Society, Vol. 369, No. 1638 ( 2014-03-19), p. 20130106-
Abstract:
The outcome of a malignant disease depends on the efficacy of the immune system to destroy cancer cells. Key steps in this process, for example the generation of a proper Ca 2+ signal induced by recognition of a specific antigen, are regulated by various ion channel including voltage-gated Kv1.3 and Ca 2+ -activated KCa3.1 K + channels, and the interplay between Orai and STIM to produce the Ca 2+ -release-activated Ca 2+ (CRAC) current required for T-cell proliferation and function. Understanding the immune cell subset-specific expression of ion channels along with their particular function in a given cell type, and the role of cancer tissue-dependent factors in the regulation of operation of these ion channels are emerging questions to be addressed in the fight against cancer disease. Answering these questions might lead to a better understanding of the immunosuppression phenomenon in cancer tissue and the development of drugs aimed at skewing the distribution of immune cell types towards killing of the tumour cells.
Type of Medium:
Online Resource
ISSN:
0962-8436
,
1471-2970
DOI:
10.1098/rstb.2013.0106
Language:
English
Publisher:
The Royal Society
Publication Date:
2014
detail.hit.zdb_id:
208382-6
detail.hit.zdb_id:
1462620-2
SSG:
12
