In:
Genes & Development, Cold Spring Harbor Laboratory, Vol. 23, No. 2 ( 2009-01-15), p. 133-137
Abstract:
Regulated translation and subcellular localization of maternal mRNAs underlies establishment of the antero–posterior axis in the Drosophila oocyte. In this issue of Genes & Development , Besse et al. (pp. 195–207) show that a molecule better known as a regulator of alternative splicing in the nucleus, polypyrimidine tract-binding protein (PTB), is required for repression of oskar mRNA in the cytoplasm. Their work suggests that PTB need not engage oskar mRNA in the nucleus for efficient repression, providing an important counterexample to the increasingly popular idea that cytoplasmic regulation initiates in the nucleus.
Type of Medium:
Online Resource
ISSN:
0890-9369
,
1549-5477
Language:
English
Publisher:
Cold Spring Harbor Laboratory
Publication Date:
2009
detail.hit.zdb_id:
1467414-2
SSG:
12
