In:
Genes & Development, Cold Spring Harbor Laboratory, Vol. 32, No. 21-22 ( 2018-11-01), p. 1443-1458
Abstract:
Bcl9 and Pygopus (Pygo) are obligate Wnt/β-catenin cofactors in Drosophila , yet their contribution to Wnt signaling during vertebrate development remains unresolved. Combining zebrafish and mouse genetics, we document a conserved, β-catenin-associated function for BCL9 and Pygo proteins during vertebrate heart development. Disrupting the β-catenin–BCL9–Pygo complex results in a broadly maintained canonical Wnt response yet perturbs heart development and proper expression of key cardiac regulators. Our work highlights BCL9 and Pygo as selective β-catenin cofactors in a subset of canonical Wnt responses during vertebrate development. Moreover, our results implicate alterations in BCL9 and BCL9L in human congenital heart defects.
Type of Medium:
Online Resource
ISSN:
0890-9369
,
1549-5477
DOI:
10.1101/gad.315531.118
Language:
English
Publisher:
Cold Spring Harbor Laboratory
Publication Date:
2018
detail.hit.zdb_id:
1467414-2
SSG:
12