In:
Acta Crystallographica Section C Structural Chemistry, International Union of Crystallography (IUCr), Vol. 74, No. 5 ( 2018-05-01), p. 635-640
Abstract:
We report the isolation of a novel diterpene, designated as `amethane', from Isodon amethystoides (Lamiaceae). The diterpene [amethinol A; systematic name: (4a R ,4b R ,7 R ,10a S )-4b,7-dihydroxy-7-isopropyl-1,1-dimethyl-9-oxododecahydrobenzo[ a ]azulene-4a(2 H )-carboxylic acid], possesses a unique skeleton containing a six/five/seven-membered tricyclic system. Intermolecular O—H...O close contacts were found to the carboxyl, carbonyl and hydroxy groups, connecting molecules into a two-dimensional structure. A possible biosynthetic pathway has been proposed. In addition, the compound was evaluated for its biological activities against different disease targets, and was found to significantly attenuate RORγt-dependent autoimmune responses.
Type of Medium:
Online Resource
ISSN:
2053-2296
DOI:
10.1107/S2053229618005740
DOI:
10.1107/S2053229618005740/lg3224sup1.cif
DOI:
10.1107/S2053229618005740/lg3224Isup2.hkl
Language:
Unknown
Publisher:
International Union of Crystallography (IUCr)
Publication Date:
2018
detail.hit.zdb_id:
2025703-X