In:
The Journal of Dermatology, Wiley, Vol. 44, No. 6 ( 2017-06), p. 699-702
Abstract:
Psoriasis, an inflammatory skin disease triggered by the immune system, presents keratinocyte hyperproliferation, differentiation and angiogenesis. The role of transglutaminase‐2 ( TG 2) in psoriasis has not been fully established yet. In this retrospective, non‐randomized and non‐blinded study, skin biopsies were collected from 37 psoriatic patients and immunohistochemical staining was performed. TG 2 staining was positive in all 37 samples, among which 32 were strong and five weak. The localization of TG 2 staining was present in the epidermis and spreading from basal layer to stratum granulosum in decreasing staining intensity. However, TG 2 was also expressed in the basal layer in the non‐lesional site of psoriasis and the skin of healthy people. The presence of TG 2 was not associated with disease duration, stage of disease and subtype of psoriasis. Overexpression of TG 2 seems to be an important role in psoriatic development.
Type of Medium:
Online Resource
ISSN:
0385-2407
,
1346-8138
DOI:
10.1111/jde.2017.44.issue-6
DOI:
10.1111/1346-8138.13742
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2222121-9