In:
BJOG: An International Journal of Obstetrics & Gynaecology, Wiley, Vol. 130, No. 8 ( 2023-07), p. 968-977
Abstract:
To examine the effect of a premenopausal risk‐reducing salpingo‐oophorectomy (RRSO) in women at increased risk of ovarian cancer on objective and subjective cognition at least 10 years after RRSO. Design A cross‐sectional study with prospective follow‐up, nested in a nationwide cohort. Setting Multicentre in the Netherlands. Population or Sample 641 women (66% BRCA1/2 pathogenic variant carriers) who underwent either a premenopausal RRSO ≤ age 45 ( n = 436) or a postmenopausal RRSO ≥ age 54 ( n = 205). All participants were older than 55 years at recruitment. Methods Participants completed an online cognitive test battery and a questionnaire on subjective cognition. We used multivariable regression analyses, adjusting for age, education, breast cancer, hormone replacement therapy, cardiovascular risk factors and depression. Main Outcome Measures The influence of RRSO on objective and subjective cognition of women with a premenopausal RRSO compared with women with a postmenopausal RRSO. Results After adjustment, women with a premenopausal RRSO (mean time since RRSO 18.2 years) performed similarly on objective cognitive tests compared with women with a postmenopausal RRSO (mean time since RRSO 11.9 years). However, they more frequently reported problems with reasoning (odds ratio [OR] 1.8, 95% confidence interval [95% CI] 1.1–3.1) and multitasking (OR 1.9, 95% CI 1.1–3.4) than women with a postmenopausal RRSO. This difference between groups disappeared in an analysis restricted to women of comparable ages (60–70 years). Conclusions Reassuringly, approximately 18 years after RRSO, we found no association between premenopausal RRSO and objective cognition.
Type of Medium:
Online Resource
ISSN:
1470-0328
,
1471-0528
DOI:
10.1111/1471-0528.17415
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2036469-6