In:
Therapeutic Apheresis and Dialysis, Wiley, Vol. 18, No. 3 ( 2014-06), p. 238-243
Abstract:
Palmoplantar pustulosis ( PPP ) is characterized by neutrophilic pustules with erythema, which are limited to the hands and feet. Although granulocyte and monocyte adsorption apheresis ( GMA ) has shown remarkable effects on generalized pustular psoriasis, there are few reports of PPP treated with GMA . We treated three refractory PPP patients using GMA weekly for 5 weeks. The skin eruptions were assessed by a 5‐grade score for scales, pustules, and erythema. GMA decreased the total grade from 9 to 2 in patients 1 and 2, and from 7 to 3 in patient 3. The GMA effects were estimated to be excellent in all three patients. Pustule formation and pain disappeared in all cases. The treatment effect lasted for at least 5 months after GMA . GMA was also effective for relieving the arthralgia in one patient, but it recurred at 6 weeks. Based on these findings, GMA could be an effective therapy for refractory PPP .
Type of Medium:
Online Resource
ISSN:
1744-9979
,
1744-9987
DOI:
10.1111/tap.2014.18.issue-3
DOI:
10.1111/1744-9987.12210
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2010864-3