In:
Journal of Digestive Diseases, Wiley, Vol. 19, No. 4 ( 2018-04), p. 242-253
Abstract:
Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein (WFA + ‐M2BP) is a novel glycobiomarker for evaluating liver fibrosis, but less is known about its role in liver cirrhosis (LC). This study aimed to investigate the utility of WFA + ‐M2BP in evaluating liver function and predicting prognosis of cirrhotic patients. METHODS We retrospectively included 197 patients with LC between 2013 and 2016. Serum WFA + ‐M2BP and various biochemical parameters were measured in all patients. With a median follow‐up of 23 months, liver‐related complications and deaths of 160 patients were recorded. The accuracy of WFA + ‐M2BP in evaluating liver function, predicting decompensation and mortality were measured by the receiver operating characteristic (ROC) curve, logistic and Cox's regression analyses, respectively. RESULTS WFA + ‐M2BP levels increased with elevated Child–Pugh classification, especially in patients with hepatitis B virus (HBV) infection. ROC analysis confirmed the high reliability of WFA + ‐M2BP for the assessment of liver function using Child–Pugh classification. WFA + ‐M2BP was also significantly positively correlated with the model for end‐stage liver disease (MELD) score. Multivariate logistic regression analysis indicated WFA + ‐M2BP as an independent predictor of clinical decompensation for compensated patients (odds ratio 11.958, 95% confidence interval [CI] 1.876–76.226, P = 0.009), and multivariate Cox's regression analysis verified WFA + ‐M2BP as an independent risk factor for liver‐related death in patients with HBV infection (hazards ratio 10.596, 95% CI 1.356–82.820, P = 0.024). CONCLUSION Serum WFA + ‐M2BP is a reliable predictor of liver function and prognosis in LC and could be incorporated into clinical surveillance strategies for LC patients, especially those with HBV infection.
Type of Medium:
Online Resource
ISSN:
1751-2972
,
1751-2980
DOI:
10.1111/cdd.2018.19.issue-4
DOI:
10.1111/1751-2980.12596
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2317117-0
