In:
Journal of Diabetes, Wiley, Vol. 11, No. 2 ( 2019-02), p. 148-160
Abstract:
Highlights Effects of a 3‐day high‐fat diet (HFD) on insulin resistance (IR) and glycolipid metabolism in young obese men with hyperlipidemia was evaluated, with changes in urinary metabolomics profiling after the HFD intervention determined using ultra‐HPLC–quadrupole time‐of‐flight mass spectrometry. Short‐term HFD exacerbates IR and glycolipid metabolism disorders, and 17 major metabolites were identified that were associated with type 2 diabetes mellitus, glycolipid metabolism and IR; changes in these metabolites suggest metabolic changes in young obese males after the HFD intervention. These findings may contribute to an increased understanding of the early biological adaptations of obesity with hyperlipidemia to HFD for early prevention and control of diabetes and IR.
Type of Medium:
Online Resource
ISSN:
1753-0393
,
1753-0407
DOI:
10.1111/jdb.2019.11.issue-2
DOI:
10.1111/1753-0407.12828
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2485432-3