In:
Journal of Medical Imaging and Radiation Oncology, Wiley, Vol. 60, No. 1 ( 2016-02), p. 119-128
Abstract:
Local control, either with surgery, radiation ( RT ) or both, is essential in the management of localised E wing sarcoma; however, the relative role of RT remains controversial. Methods Using the S urveillance, E pidemiology, and E nd R esults database, 612 patients treated for non‐metastatic skeletal Ewing sarcoma between the years 1988 and 2010 were identified. Results Median age and follow‐up were 13 years (range: 0–21) and 56 months (range: 0–287), respectively. Five‐year overall survival ( OS ) for the cohort was 74.4 ± 2.0%. Patients received surgery alone (51.3%), RT alone (21.6%) or both (27.1%). Patients with skeletal E wing sarcoma had improved OS with surgery alone compared with other treatments. However, in subset analyses, RT was not inferior to surgery alone for appendicular (5‐year OS : 80.0% vs. 79.3%), non‐pelvic (84.3% vs. 79.9%) or localised disease (confined to cortex or periosteum; 79.7% vs. 80.6%). After controlling for stage and site, no increase in mortality was observed with RT versus surgery alone (hazard ratio = 0.77 (95% confidence interval: 0.49–1.19)). Conclusions I n regard to survival, RT did not appear to be inferior to surgery alone for most patients, particularly those with disease at favourable sites (localised, appendicular, non‐pelvic). In select patients with E wing sarcoma, RT may be an appropriate strategy for local control that does not necessarily compromise survival outcomes.
Type of Medium:
Online Resource
ISSN:
1754-9477
,
1754-9485
DOI:
10.1111/jmiro.2016.60.issue-1
DOI:
10.1111/1754-9485.12389
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2409071-2
