In:
Thoracic Cancer, Wiley, Vol. 6, No. 4 ( 2015-07), p. 433-442
Kurzfassung:
To evaluate the role of computed tomography ( CT) and positron emission tomography ( PET) / CT in patients with thymic cancer and thymoma at initial staging. Methods We retrospectively reviewed CT and PET / CT scans of 26 patients with a thymic cancer ( n = 9) or thymoma ( n = 17). Chest CT findings documented were qualitative and quantitative. Both qualitative and semiquantitative data were recovered by PET / CT . The comparisons among histological entities, outcome, and qualitative data from CT and PET / CT were made by non‐parametric analysis. Results PET / CT resulted positive in 15/17 patients with thymoma. CT was available in 5/9 (56%) patients with thymic cancer and in 3/17 with thymoma. All quantitative CT parameters were significantly higher in patients with thymic cancer than thymoma (maximum axial diameter: 45 vs. 20 mm, maximum longitudinal diameter: 69 vs. 21 mm and volume: 77.91 vs. 4.52 mL; all P 〈 0.05). Conversely, only metabolic tumor volume ( MTV ) and total lesion glycolysis were significantly different in patients with thymic cancer than thymoma (126.53 vs. 6.03 cm3 and 246.05 vs. 20.32, respectively; both P 〈 0.05). After a median follow‐up time of 17.45 months, four recurrences of disease occurred: three in patients with thymic cancer and one with a type B2 thymoma. CT volume in patients with recurrent disease was 102.19 mL versus a median value of 62.5 mL in six disease‐free patients. MTV was higher in the recurrent than disease‐free patient subset (143.3 vs. 81.13 cm 3 ), although not statistically significant ( P = 0.075). Conclusion Our preliminary results demonstrated that both morphological and metabolic volume could be useful from a diagnostic and prognostic point of view in thymic cancer and thymoma patients. A large multi‐center clinical trial experience for confirming the findings of this study seems mandatory.
Materialart:
Online-Ressource
ISSN:
1759-7706
,
1759-7714
DOI:
10.1111/tca.2015.6.issue-4
DOI:
10.1111/1759-7714.12197
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
2559245-2
