In:
Acta Paediatrica, Wiley, Vol. 102, No. 8 ( 2013-08)
Kurzfassung:
There is a need to identify infants with hypoxic ischaemic encephalopathy who have a poor outcome despite therapeutic hypothermia. A severely abnormal amplitude‐integrated electroencephalogram at 48 h predicts death or disability. Our aim was to determine whether clinical assessment at age 3–5 h predicts a severely abnormal amplitude‐integrated electroencephalogram at 48 h or death in cooled infants. Methods Forty‐one cooled infants, ≥36 weeks' gestation, with moderate‐to‐severe hypoxic ischaemic encephalopathy, were prospectively enrolled. Infants who were moribund, had congenital conditions associated with encephalopathy or had severe cardio‐respiratory instability were excluded. The predictive abilities of the T hompson encephalopathy score and individual signs at age 3–5 h were assessed. Results All infants with a T hompson score ≥16 at 3–5 h had a severely abnormal amplitude‐integrated electroencephalogram at 6 h and an abnormal short‐term outcome. At 48 h, 75% had a severely abnormal a EEG or died vs. 18% with a score 〈 16 (p = 0.004). Multivariate analysis did not find a significant independent association with any of the individual signs. Conclusion The T hompson score could be useful to identify infants who will have a poor outcome despite cooling. A score ≥16 should be validated as a prespecified variable in prospective studies.
Materialart:
Online-Ressource
ISSN:
0803-5253
,
1651-2227
DOI:
10.1111/apa.2013.102.issue-8
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2013
ZDB Id:
1492629-5
ZDB Id:
1501466-6