In:
Acta Paediatrica, Wiley, Vol. 104, No. 5 ( 2015-05)
Abstract:
The aim of this study was to examine the association between allergic bronchopulmonary aspergillosis ( ABPA ) and poorly controlled asthma in children and appraise the diagnostic criteria. Methods The study included 100 children with poorly controlled asthma. We diagnosed ABPA using the Aspergillus skin test, pulmonary function test, total and specific immunoglobulin E (IgE) to Aspergillus fumigatus, chest radiograph and high‐resolution computed tomography. Patients were diagnosed and classified according to the Rosenberg–Patterson criteria for ABPA . The cut‐off value for total serum IgE was calculated by receiver operating characteristics curve analysis. Results Of 100 children with poorly controlled asthma, 26 patients were ABPA positive. There was a significant difference in the forced expiratory volume in 1‐sec/forced vital capacity ratio between ABPA positive (0.78 ± 0.14) and negative (0.87 ± 0.15) children (p = 0.008). ABPA positive children were categorised as seropositive, central bronchiectasis and other radiological findings. The receiver operating characteristics curve was constructed, and a value of 1200 IU / mL of total IgE was observed, with 88.5% sensitivity and 70.5% specificity. Conclusion This study showed an association between ABPA and poorly controlled asthma in children and suggests a higher cut‐off value of total IgE for the diagnosis of ABPA .
Type of Medium:
Online Resource
ISSN:
0803-5253
,
1651-2227
DOI:
10.1111/apa.2015.104.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1492629-5
detail.hit.zdb_id:
1501466-6
