In:
Acta Paediatrica, Wiley, Vol. 112, No. 10 ( 2023-10), p. 2182-2188
Abstract:
The incidence of anaphylaxis is increasing globally in tandem with changing environmental and lifestyle factors. There is very limited data on very early childhood presentations. We aim to assess changes in rates, characteristics and management of infant anaphylaxis in a paediatric ED over a 15‐year period. Methods We conducted a retrospective study of children 〈 2 years of age who presented with verified anaphylaxis comparing cases in years 2003–2007 with those in 2013–2017. Standardised information was collected on demographics, clinical presentation, management and triggers. Results Manually confirmed anaphylaxis rates in 〈 2 year olds increased from 3.6 to 6.2 per 10 4 population (OR 1.7, 95% CI: 1.3–2.7; p 〈 0.001) with the greatest increase in 〈 1 year olds. Anaphylaxis severity increased between 2003–2007 and 2013–2017 (OR 2.3, 95% CI: 1.2–4.3; p = 0.018). Failure to administer adrenaline was reduced in 2013–2017 ( p = 0.007). Food was the leading anaphylaxis trigger (97.85%). Conclusion This is the first study to suggest an increase in the incidence and severity of ED anaphylaxis presentations in children aged 〈 2 years. Increased awareness of specific characteristics in this age group is required to facilitate timely recognition and optimal management. Further large‐scale studies are warranted to understand underlying environmental drivers and find prevention strategies to reduce the burden of disease.
Type of Medium:
Online Resource
ISSN:
0803-5253
,
1651-2227
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
1492629-5
detail.hit.zdb_id:
1501466-6
