In:
Acta Physiologica, Wiley, Vol. 229, No. 3 ( 2020-07)
Kurzfassung:
The body responds to exercise training by profound adaptations throughout the cardiorespiratory and muscular systems, which may result in improvements in maximal oxygen consumption (VO 2 peak) and mitochondrial capacity. By convenience, mitochondrial respiration is often measured at supra‐physiological oxygen levels, an approach that ignores any potential regulatory role of mitochondrial affinity for oxygen (p50 mito ) at physiological oxygen levels. Methods In this study, we examined the p50 mito of mitochondria isolated from the Vastus lateralis and Triceps brachii in 12 healthy volunteers before and after a training intervention with seven sessions of sprint interval training using both leg cycling and arm cranking. The changes in p50 mito were compared to changes in whole‐body VO 2 peak. Results We here show that p50 mito is similar in isolated mitochondria from the Vastus (40 ± 3.8 Pa) compared to Triceps (39 ± 3.3) but decreases (mitochondrial oxygen affinity increases) after seven sessions of sprint interval training (to 26 ± 2.2 Pa in Vastus and 22 ± 2.7 Pa in Triceps , both P 〈 .01). The change in VO 2 peak modelled from changes in p50 mito was correlated to actual measured changes in VO 2 peak ( R 2 = .41, P = .002). Conclusion Together with mitochondrial respiratory capacity, p50 mito is a critical factor when measuring mitochondrial function, it can decrease with sprint interval training and should be considered in the integrative analysis of the oxygen cascade from lung to mitochondria.
Materialart:
Online-Ressource
ISSN:
1748-1708
,
1748-1716
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2020
ZDB Id:
2617148-X
ZDB Id:
2219379-0
SSG:
12
