In:
Animal Science Journal, Wiley, Vol. 90, No. 6 ( 2019-06), p. 781-789
Kurzfassung:
Skeletal muscle fiber is largely classified into two types: type 1 (slow‐twitch) and type 2 (fast‐twitch) fibers. Meat quality and composition of fiber types are thought to be closely related. Previous research showed that overexpression of constitutively active peroxisome proliferator‐activated receptor ( PPAR )δ, a nuclear receptor present in skeletal muscle, increased type 1 fibers in mice. In this study, we found that hexane extracts of Yamabushitake mushroom ( Hericium erinaceus ) showed PPAR δ agonistic activity in vitro . Eight‐week‐old C57 BL /6J mice were fed a diet supplemented with 5% (w/w) freeze‐dried Yamabushitake mushroom for 24 hr. After the treatment period, the extensor digitorum longus ( EDL ) muscles were excised. The Yamabushitake‐supplemented diet up‐regulated the PPAR δ target genes Pdk4 and Ucp3 in mouse skeletal muscles in vivo . Furthermore, feeding the Yamabushitake‐supplemented diet to mice for 8 weeks resulted in a significant increase in muscle endurance. These results indicate that Yamabushitake mushroom contains PPAR δ agonistic ligands and that dietary intake of Yamabushitake mushroom could activate PPAR δ in skeletal muscle of mice. Unexpectedly, we observed no significant alterations in composition of muscle fiber types between the mice fed control and Yamabushitake‐supplemented diets.
Materialart:
Online-Ressource
ISSN:
1344-3941
,
1740-0929
DOI:
10.1111/asj.2019.90.issue-6
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2019
ZDB Id:
2095161-9