In:
Basic & Clinical Pharmacology & Toxicology, Wiley, Vol. 115, No. 1 ( 2014-07), p. 134-144
Abstract:
Human exposure to persistent organic pollutants ( POP s) is of major concern due to a diversity of adverse effects from prolonged exposure and bioaccumulation. Manufacturing of polychlorinated biphenyls ( PCB s), a subgroup of POP s, has been prohibited for many decades; however, human exposure still occurs due to the persistent nature of the chemicals. The concentrations of the dioxin‐like PCB congeners 105, 118 and 156 and the non‐dioxin‐like PCB congeners 28, 52, 101, 138, 153 and 180, p,p′ ‐ DDE , p,p′ ‐ DDT , o,p′‐ DDE , o,p′‐ DDT , HCB and β‐ HCH as well as the dioxin‐like activity using the A h R transactivity assay were analysed in blood samples from D anish schoolchildren and their mothers in the European framework of the DEMOCOPHES / COPHES projects. The participants were selected from an urban and a rural area, respectively. The PCB concentrations and the A h R ‐ TEQ ( TCDD toxic equivalent) were significantly higher in schoolchildren living in the urban area compared with the rural, and for A h R ‐ TEQ , a strong correlation between the mothers and children was observed. We found a significant negative correlation between BMI and PCB concentrations in the children. Finally, in the mothers, there was a positive association between age and PCB concentration. These results show that both PCB s and dioxin‐like activity can be measured as biomarkers of exposure and effects in blood samples from children and women. The results indicate that people living in urban areas may be exposed to higher concentrations of PCB s, dioxins and dioxin‐like chemicals, which may lead to a greater risk of adverse effects for urban populations.
Type of Medium:
Online Resource
ISSN:
1742-7835
,
1742-7843
DOI:
10.1111/bcpt.2014.115.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2151592-X
SSG:
15,3
