In:
British Journal of Haematology, Wiley, Vol. 183, No. 4 ( 2018-11), p. 636-647
Abstract:
An ancillary analysis to the SepsiCoag multicentric prospective observational study on patients entering an intensive care unit with septic shock evaluated the prognostic potential of fibrin generation markers ( FGM s) tested at inclusion in the study, on survival at day 30. After centralization of samples, three automated FGM s were compared: D‐dimers (DDi), fibrin/fibrinogen degradation products ( FDP ) and fibrin monomers ( FM ). FM was the single FGM that was significantly higher in non‐surviving patients, area under the receiver‐operator characteristic curve (AUC ROC ): 0·617, P 〈 0·0001. Significantly higher International Society on Thrombosis and Haemostasis Disseminated Intravascular Coagulation ( ISTH DIC ) scores were calculated in non‐survivors using each of the three FGM s. A dose‐effect relationship was observed between ISTH DIC scores and non‐survival, with highest significance obtained using FM as the FGM . An overt DIC diagnosis using the ISTH DIC score calculated using FM was a predictor of non‐survival at day 30, independently from overt DIC diagnosis based on scores calculated using FDP or DDi . The AUC ROC values testing the ability of the ISTH DIC score to predict non‐survival were 0·650, 0·624 and 0·602 using FM , DDi and FDP , respectively, as the FGM . In patients with septic shock, among the commercially‐available automated assays, automated FM is the FGM best related with late prognosis.
Type of Medium:
Online Resource
ISSN:
0007-1048
,
1365-2141
DOI:
10.1111/bjh.2018.183.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1475751-5