In:
BJU International, Wiley, Vol. 113, No. 3 ( 2014-03), p. 399-407
Abstract:
To examine whether percentage of tumour volume (% TV ) and percentage of high‐grade tumour volume (% HGTV ) help to better identify men at higher risk of early biochemical recurrence ( BCR ) after radical prostatectomy ( RP ) for non‐metastatic high‐risk prostate cancer, as early BCR after RP might be associated with higher risk of metastases and cancer‐specific mortality. Patients and Methods We examined the data of 595 men treated with RP for non‐metastatic high‐risk prostate cancer between 1992 and 2011 at two E uropean tertiary care centres. Kaplan– M eier analyses were used to graphically depict 2‐year BCR ‐free survival. Multivariable C ox regression models addressed early BCR . We tested whether addition of % TV and % HGTV to a multivariable C ox regression model helps to increase a model's predictive accuracy ( PA ) for prediction of early BCR . Results In all, 32 men (10%) with specimen‐confined prostate cancer ( pT2 – pT3a , negative surgical margin, pN0 ) and 67 men (24%) with non‐specimen‐confined prostate cancer had early BCR . After stratification according to % HGTV (% HGTV threshold: ≤33.33 vs 〉 33.33%), the 2‐year BCR ‐free survival rates were respectively 93 vs 60% (log‐rank P 〈 0.001). In multivariable C ox regression models % HGTV emerged as an independent predictor of early BCR ( P 〈 0.001), whereas % TV did not ( P 〉 0.05). However, adding % HGTV (regardless of its coding) to other covariates in multivariable C ox regression analysis did not increase the model's PA in a meaningful fashion compared with the use of the detailed G leason grading system (6 vs 7a vs 7b vs 8 vs 9–10). Conclusions In a large cohort of patients with high‐risk prostate cancer, % HGTV and % TV did not improve prediction of early BCR after RP substantially, although % HGTV was an independent predictor of early BCR . Therefore, sophisticated TV / HGTV measurements do not seem to have additional benefit for early BCR prediction relative to the use of G leason grading. However, these results need to be confirmed in larger, prospective studies.
Type of Medium:
Online Resource
ISSN:
1464-4096
,
1464-410X
DOI:
10.1111/bju.2014.113.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2019983-1