In:
BJU International, Wiley, Vol. 114, No. 3 ( 2014-09), p. 340-343
Kurzfassung:
To assess the role of centralized pathological review in penile cancer management. Materials and Methods Newly diagnosed squamous cell carcinomas (SCC) of the penis, including squamous cell carcinoma in situ ( CIS ), from biopsy specimens were referred from 15 centres to the regional supra‐network multidisciplinary team ( S n‐ MDT ) between 1 J anuary 2008 and 30 M arch 2011. Biopsy histology reports and slides from the respective referring hospitals were reviewed by the S n‐ MDT pathologists. The biopsy specimens’ histological type, grade and stage reported by the S n‐ MDT pathologist were compared with those given in the referring hospital pathology report, as well as with definitive surgery histology. Any changes in histological diagnosis were sub‐divided into critical changes (i.e. those that could alter management) and non‐critical changes (i.e. those that would not affect management). Results A total of 155 cases of squamous cell carcinoma or CIS of the penis were referred from 15 different centres in N orth‐ W est E ngland. After review by the S n‐ MDT , the histological diagnosis was changed in 31% of cases and this difference was statistically significant. A total of 60.4% of the changes were deemed to be critical changes that resulted in a significant change in management. When comparing the biopsy histology reported by the S n‐ MDT with the final histology from the definitive surgical specimens, a good correlation was generally found. Conclusions In the present study a significant proportion of penile cancer histology reports were revised after review by the S n‐ MDT . Many of these changes altered patient management. The present study shows that accurate pathological diagnosis plays a crucial role in determining the correct treatment and maximizing the potential for good clinical outcomes in penile cancer. In the case of histopathology, centralization has increased exposure to penile cancer and thereby increased diagnostic accuracy, and should therefore be considered the ‘gold standard’.
Materialart:
Online-Ressource
ISSN:
1464-4096
,
1464-410X
DOI:
10.1111/bju.2014.114.issue-3
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
2019983-1
