In:
Biology of the Cell, Wiley, Vol. 105, No. 9 ( 2013-09), p. 373-398
Abstract:
Connexin (Cx) and pannexin (Panx) proteins form large conductance channels, which function as regulators of communication between neighbouring cells via gap junctions and/or hemichannels. Intercellular communication is essential to coordinate cellular responses in tissues and organs, thereby fulfilling an essential role in the spreading of signalling, survival and death processes. The functional properties of gap junctions and hemichannels are modulated by different physiological and pathophysiological stimuli. At the molecular level, Cxs and Panxs function as multi‐protein channel complexes, regulating their channel localisation and activity. In addition to this, gap junctional channels and hemichannels are modulated by different post‐translational modifications (PTMs), including phosphorylation, glycosylation, proteolysis, N‐acetylation, S‐nitrosylation, ubiquitination, lipidation, hydroxylation, methylation and deamidation. These PTMs influence almost all aspects of communicating junctional channels in normal cell biology and pathophysiology. In this review, we will provide a systematic overview of PTMs of communicating junction proteins and discuss their effects on Cx and Panx‐channel activity and localisation.
Type of Medium:
Online Resource
ISSN:
0248-4900
,
1768-322X
DOI:
10.1111/boc.2013.105.issue-9
DOI:
10.1111/boc.201200096
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2011750-4
SSG:
12