In:
Cancer Science, Wiley, Vol. 105, No. 2 ( 2014-02), p. 150-158
Kurzfassung:
Regulatory T cells (Tregs) and plasmacytoid dendritic cells (p DC s) play important roles in the immune escape of cancer. In this study, we investigated p DC s and p DC ‐induced inducible costimulator ( ICOS ) + Treg populations in peripheral blood from gastric cancer ( GC ) patients and healthy donors by flow cytometry. The distribution of these cells in carcinoma tissue, peritumor tissue, and normal gastric mucosa was detected by immunohistochemistry. Plasma and tissue concentration of the cytokines such as interleukin‐10 and transforming growth factor‐β1 were also measured. We found that the numbers of p DC s, Tregs, and ICOS + Tregs in peripheral blood were increased in GC patients compared with healthy donors. In tissue, Tregs and ICOS + Tregs were found distributing mainly in carcinoma tissue, whereas p DC s were mainly found in peritumor tissue. Moreover, the Foxp3 + ICOS + /Foxp3 + cell ratio in carcinoma and peritumor tissue were higher than that in normal tissue. There were more ICOS + Tregs in tumor and peritumor tissue of late‐stage GC patients. There was a positive correlation between p DC s and ICOS + Tregs in peripheral blood and peritumor tissue from GC patients. In conclusion, p DC s may play a potential role in recruiting ICOS + Tregs, and both participate in the immunosuppression microenvironment of GC .
Materialart:
Online-Ressource
ISSN:
1347-9032
,
1349-7006
DOI:
10.1111/cas.2014.105.issue-2
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
2115647-5
ZDB Id:
2111204-6