In:
Cancer Science, Wiley, Vol. 108, No. 4 ( 2017-04), p. 653-662
Kurzfassung:
Emerging evidence has indicated that deregulation of long non‐coding RNA s (lnc RNA s) can contribute to the progression and metastasis of human cancer, including hepatocellular carcinoma ( HCC ). However, the roles of most lnc RNA s in HCC remain largely unknown. Here we found a long noncoding RNA termed Sch LAH (seven chromosome locus associated with HCC ; also called BC 035072) was generally downregulated in HCC . Low expression of Sch LAH was significantly correlated with shorter overall survival of HCC patients. In vitro and in vivo assays indicated that overexpression of Sch LAH inhibited the migration and lung metastasis of HCC cells. Knockdown of Sch LAH by si RNA pool promoted the migration of HCC cells. RNA pull‐down and RNA immunoprecipitation assays demonstrated Sch LAH physically interacted with fused in sarcoma ( FUS ). PCR array analysis showed that RhoA and Rac1 were the downstream effector molecules of Sch LAH during HCC metastasis. Knockdown of FUS rescued the mRNA levels of RhoA and Rac1 that were repressed by Sch LAH . These results suggest that Sch LAH may suppress the metastasis of HCC cells by interacting with FUS , which indicates potential of Sch LAH for the prognosis and treatment of HCC .
Materialart:
Online-Ressource
ISSN:
1347-9032
,
1349-7006
DOI:
10.1111/cas.2017.108.issue-4
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2017
ZDB Id:
2115647-5
ZDB Id:
2111204-6
