In:
Cancer Science, Wiley, Vol. 113, No. 9 ( 2022-09), p. 2986-3001
Abstract:
Functional analyses demonstrated that TPT1‐AS1 could promote pancreatic cancer cell proliferation, invasion, migration, and epithelial‐to‐mesenchymal transition (EMT) process in vitro and in vivo. Mechanistically, TPT1‐AS1 directly bound to miR‐30a‐5p and served as a ceRNA to upregulate ITGB3 expression. In turn, ITGB3 could increase the expression of TPT1‐AS1 via activating STAT3, thus forming a positive feedback loop. These findings demonstrate TPT1‐AS1 could serve as an oncogene in pancreatic cancer, which might provide potential diagnostic and therapeutic targets for pancreatic cancer patients. image
Type of Medium:
Online Resource
ISSN:
1347-9032
,
1349-7006
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2115647-5
detail.hit.zdb_id:
2111204-6
