In:
Chemical Biology & Drug Design, Wiley, Vol. 88, No. 4 ( 2016-10), p. 608-614
Kurzfassung:
A novel series of 4‐oxo‐ N ‐(4‐hydroxyphenyl) retinamide (4‐oxo‐4‐ HPR ) derivatives were synthesized with the aim of increasing the poor solubility of the parent compound in biological fluids, while maintaining the cytotoxic activity and the dual mechanism of action. The most promising compound 13a showed antiproliferative/apoptotic activity. The analysis of its mechanism of action revealed that it retained the particular characteristic of 4‐oxo‐4‐ HPR which is able to induce cell cycle arrest during the mitotic phase, coupled with the formation of aberrant mitotic spindles.
Materialart:
Online-Ressource
ISSN:
1747-0277
,
1747-0285
DOI:
10.1111/cbdd.2016.88.issue-4
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2016
ZDB Id:
2216600-2
SSG:
12