In:
Clinical Endocrinology, Wiley, Vol. 81, No. 4 ( 2014-10), p. 600-605
Kurzfassung:
A relationship between vestibular disorders and thyroid autoimmunity independently from thyroid function has been postulated. Aim To shed more light on the actual relationship between vestibular lesions and Hashimoto's thyroiditis ( HT ) regardless of thyroid function. Methods Forty‐seven patients with HT (89·4% F; aged 48·3 ± 12·7 years), 21 with multinodular goitre ( MNG ; 57·1% F; 54·1 ± 9·8 years) and 30 healthy volunteers (56·7% F; 50·7 ± 13·9 years) were enrolled. Inclusion criteria were the presence of normal thyroid function tests and no clinical history of vestibular dysfunction. Each subject was submitted to complete vestibular evaluation [Caloric Test, Vestibular evoked myogenic potentials ( VEMP s), Head Shaking Test ( HST )]. Results 52·2% of HT patients showed an alteration of VEMP s and 44·7% of caloric test ( P 〈 0·0001 for both). None of the MNG patients showed any vestibular alteration, while one healthy control showed an altered caloric test. A correlation was found between vestibular alterations of HT patients and the degree of serum TPOA b level, not affected by age and serum TSH value. By logistic regression analysis, the absence of thyroid autoimmunity significantly reduced the risk of vestibular alterations: HR 0.19 (95% CI : 0·003–0.25, P = 0·0004) for caloric test; HR 0·07 (95% CI : 0·02–0·425, P 〈 0·0001) for VEMP s; and HR 0·22 (95% CI : 0·06–0·7, P = 0·01) for HST . Conclusion In euthyroid HT patients, a significant relationship between subclinical vestibular damage and the degree of TPOA b titre was documented. This finding suggests that circulating antithyroid autoantibodies may represent a risk factor for developing vestibular dysfunction. An accurate vestibular evaluation of HT patients with or without symptoms is therefore warranted.
Materialart:
Online-Ressource
ISSN:
0300-0664
,
1365-2265
DOI:
10.1111/cen.2014.81.issue-4
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
2004597-9
