In:
Contact Dermatitis, Wiley, Vol. 70, No. 1 ( 2014-01), p. 27-34
Kurzfassung:
Loss‐of‐function mutations in the filaggrin gene ( FLG ) have been associated with reduced skin barrier function, possibly allowing increased penetration of irritants and allergens. Objectives To study whether FLG loss‐of‐function mutation carriers show different rates of sensitization to common type I and IV allergens among patients referred for occupational contact dermatitis of the hands. Materials and Methods Four hundred and ninety‐six Caucasian patients were genotyped for four FLG null mutations and patch tested with the European baseline series. In addition, 431 patients underwent prick testing with common type I allergens. Results Overall, 67 patients showed a heterozygous mutation in the FLG alleles R501X , R2447X , S3247X , and/or 2282del4. Sensitization rates for type I allergens from a European prick test series did not show significant differences between FLG loss‐of‐function mutation carriers and wild‐type subjects. For type IV allergens, significantly more FLG loss‐of‐function carriers were found to be sensitized to lanolin and p ‐tert‐butylphenol‐formaldehyde resin. Conclusions Probably a variety of immunological mechanisms other than that resulting from the filaggrin system have an impact on allergic sensitization to a greater degree. Larger cohorts may be necessary to increase the statistical power of the findings presented regarding type I and IV sensitization.
Materialart:
Online-Ressource
ISSN:
0105-1873
,
1600-0536
DOI:
10.1111/cod.2014.70.issue-1
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
2027120-7
