In:
Cell Proliferation, Wiley, Vol. 56, No. 3 ( 2023-03)
Abstract:
The role of hydrogen sulphide (H 2 S) in angiogenesis has been widely demonstrated. Vascular endothelial growth factor (VEGF) plays an important role in H 2 S‐induced angiogenesis. H 2 S promotes angiogenesis by upregulating VEGF via pro‐angiogenic signal transduction. The involved signalling pathways include the mitogen‐activated protein kinase pathway, phosphoinositide‐3 kinase pathway, nitric oxide (NO) synthase/NO pathway, signal transducer and activator of transcription 3 (STAT3) pathway, and adenosine triphosphate (ATP)‐sensitive potassium (K ATP ) channels. H 2 S has been shown to contribute to tumour angiogenesis, diabetic wound healing, angiogenesis in cardiac and cerebral ischaemic tissues, and physiological angiogenesis during the menstrual cycle and pregnancy. Furthermore, H 2 S can exert an anti‐angiogenic effect by inactivating Wnt/β‐catenin signalling or blocking the STAT3 pathway in tumours. Therefore, H 2 S plays a double‐edged sword role in the process of angiogenesis. The regulation of H 2 S production is a promising therapeutic approach for angiogenesis‐associated diseases. Novel H 2 S donors and/or inhibitors can be developed in the treatment of angiogenesis‐dependent diseases.
Type of Medium:
Online Resource
ISSN:
0960-7722
,
1365-2184
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2019986-7
SSG:
12