In:
The Clinical Respiratory Journal, Wiley, Vol. 8, No. 4 ( 2014-10), p. 455-459
Kurzfassung:
Cystic fibrosis ( CF ) patients have a susceptibility to vitamin D deficiency because of nutrient malabsorption. Objectives To evaluate the prevalence of hypovitaminosis D in CF patients and the factors associated with serum 25‐hydroxyvitamin D levels. Methods We evaluated the prevalence of vitamin D deficiency defined as 25‐hydroxyvitamin D 〈 30 ng/m L , as suggested recently by the C ystic F ibrosis F oundation, and factors associated with its serum levels. Patients with confirmed CF were included. Nutritional status and hospital admissions were evaluated. Serum C ‐reactive protein, calcium, phosphate, magnesium, albumin, 25‐hydroxyvitamin D and parathyroid hormone levels were measured. Lung function was evaluated by spirometry, and clinical and chest radiographic scores were assessed. Statistical significance level was set at P 〈 0.05. Results Fifty‐nine patients were included. Prevalence of hypovitaminosis D was 61%. Patients with pancreatic insufficiency had a trend to have higher vitamin D levels. Sixteen patients had severe lung disease with percentage of forced expiratory volume in 1 s predicted below 40%. After multivariate analysis, body mass index and hospitalization in the last month remained significantly associated with serum vitamin D levels. Conclusions Vitamin D insufficiency is still a problem in CF patients, even in those receiving supplementation.
Materialart:
Online-Ressource
ISSN:
1752-6981
,
1752-699X
DOI:
10.1111/crj.2014.8.issue-4
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
2442214-9
