In:
Journal of Cutaneous Pathology, Wiley, Vol. 49, No. 2 ( 2022-02), p. 116-122
Kurzfassung:
Expression of microRNA‐21 (miR‐21) is increased in psoriasis, leading to reduced levels of epidermal tissue inhibitor of matrix metalloproteinase 3 (TIMP‐3), a highly potent inhibitor of the tumor necrosis factor alpha (TNFα) sheddase TACE (TNFα‐converting enzyme)/ADAM17. We described the profile of miR‐21 and TIMP‐3 in paradoxical psoriasiform reactions induced by anti‐TNFα drugs and in a control group to elucidate the pathogenesis of this reactions. Methods We performed an analytic, cross‐sectional, prospective, experimental case‐control study. We compared our findings with those of non‐induced psoriasis. Results We included 15 patients with a change of morphology (plaque to guttate psoriasis) and 10 patients with induced psoriasis (six palmoplantar pustulosis and four plaque psoriasis). Consecutive patients with different subtypes of non‐induced, non‐systemically treated psoriasis were included as a control group. We found that most cases with guttate psoriasis and with induced plaque psoriasis cases showed high expression of TIMP‐3 expression and decreased or poorly increased levels of miR‐21. The expression pattern was not homogeneous in the cases of induced palmoplantar pustulosis. These profiles differ from those of non‐induced psoriasis. Conclusion We conclude that various pro‐inflammatory cytokine profiles are involved in the pathogenesis of paradoxical psoriasiform reactions and non‐induced psoriasis.
Materialart:
Online-Ressource
ISSN:
0303-6987
,
1600-0560
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2022
ZDB Id:
2018100-0
